Serrated Polyposis Syndrome (SPS)

At a glance…

• Close relatives may also need screening even if the inheritance pattern is less clear
• Multiple serrated polyps in the bowel
• Exact genetic cause not fully understood
• Increases risk of bowel cancer
• Often no symptoms until later — regular checks are essential

What the syndrome is and what it means for you and your family

SPS is a condition where someone develops many serrated polyps in the bowel. Unlike other syndromes, the exact genetic cause is not yet fully understood. People with SPS do have a higher risk of bowel cancer, but with regular checks and treatment, this risk can be managed.

What symptoms to look out for

Most people with SPS do not have symptoms. When symptoms do occur, they may include:

• Blood in the poo
• Changes in bowel habits
• Anaemia (tiredness, pale skin, or shortness of breath)

About the gene differences

Unlike other syndromes, no single gene difference has been identified for most cases of SPS. Research is ongoing to better understand the causes.

How it runs in families

The exact pattern is less clear than with other syndromes. Some families may see more than one person affected, while others do not. Family members of people with SPS may still be offered screening.

How it is diagnosed

• Colonoscopy showing multiple serrated polyps
• Careful review by a gastroenterologist
• Family history may also provide useful information

Screening and treatment

• Regular colonoscopies to remove polyps and reduce cancer risk
• In some cases, more frequent checks depending on the number of polyps
• Ongoing monitoring for bowel cancer

Possible surgery options

If there are too many polyps to manage safely during colonoscopies, surgery may be considered to remove part of the bowel. This is less common than in other polyposis conditions.

Health and lifestyle tips

• Attend all recommended colonoscopies
• Eat a balanced diet with plenty of fibre, fruit, and vegetables
• Limit alcohol and avoid smoking
• Stay physically active

Planning a family

Because the genetics of SPS are not fully understood, there are currently no specific tests for children or family planning. However, it is a good idea for close family members to discuss screening with their doctor.